Los ácidos micólicos, en específico, poseen funciones biológicas importantes, entre las que se encuentra el papel que desempeñan en la persistencia de la. como los ácidos micólicos, ácido micoserósido, fenoltiocerol, lipoarabinomanano y arabinogalactano contribuyen a la longevidad, a la respuesta inflamatoria. Aunque el análisis de los lípidos de la pared celular (ácidos micólicos) mediante cromatografía líquida de alta presión es una opción Buena y bien conocida, los.

Author: Yozuru Tozshura
Country: Kazakhstan
Language: English (Spanish)
Genre: Education
Published (Last): 21 May 2010
Pages: 468
PDF File Size: 13.95 Mb
ePub File Size: 16.20 Mb
ISBN: 919-1-64956-144-8
Downloads: 95591
Price: Free* [*Free Regsitration Required]
Uploader: Mauzuru

Does antibody to mycobacterial antigens, including lipoarabinomannan, limit dissemination in childhood tuberculosis? Obtainment and partial characterization of a lipidic fragment of the outer membrane of Mycobacterium smegmatis.

Ácido micólico

Mainly we identified the presence of phospholipids and micolic acids in the lipid extract showing a high recognition by human gammaglobulin. J Gen Appl Microbiol ; Oxford University Press, Targeting tuberculosis and malaria through inhibition of enoyl reductase: A lipid extract of Mycobacterium smegmatis cell wall was characterized using a Thin Layer Chromatography and Dot blot with human gammaglobulin.

Ciudad de la Habana, Cuba. Infect Dis Clin N Am ; Dot blot de fosfolipidos extraidos de Mycobacterium smegmatis.

There was a problem providing the content you requested

J Biol Chem ; Role of a branching mannosyltransferase. Chemotherapy of experimental tuberculosis – VII. Pyrrolidine micolicoos as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis.


All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Isonicotinic acid hydrazide nydrazid and related compounds. Mechanistic diversity and regulation of Type II fatty acid synthesis. Drug Targetsv. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP CoA reductase from Mycobacterium tuberculosis. Chemoterapy of experimental tuberculosis.

Entre estos factores se encuentran: Water Res ; The envelope of mycobateria. Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. De acuerdo con los resultados obtenidos mediante el micolicks de la cromatografia en capa delgada y el Dot blot, se puede afirmar que se obtuvo un extracto de pared de M. In view of this severe situation, the new and selective anti-TB design is of utmost importance.

Ácido micólico – Wikipedia, a enciclopedia libre

Drug sensitivity and environmental adaptation of mycobacterial cell wall components. The envelope of mycobacteria. Broad spectrum antimicrobial biocides target the FabI component of fatty acid biosynthesis. High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. Discovery of a novel and potent class of FabI-directed antibacterial agents.

Identification of the surface-exposed lipids on the cell envelopes of Mycobacterium tuberculosis and other mycobacterial species. Brennan PJ, Nikaido H.

The practice of medicinal chemistry. The enoyl-reductases are essential enzymes in the fatty acids elongation pathway towards the mycolic acids, the main mycobacteria cell wall constituents, biosynthesis and so they are potential targets to the rational new antimycobacteria drug design. The history of the Ziehl-Neelsen stain. Inhibition of InhA, the enoyl reductase acidoa Mycobacterium tuberculosisby triclosan and isoniazid. Overexpression of inhA, but not kasAconfers resistance to isoniazid and ethionamide in Mycobacterium smegmatisM.


Strategies in the search for new lead compounds or original working hypothesis. Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. The mechanism of isoniazid killing: Receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives.

Lepr Rev ; 68 4: Preparation and antibacterial activities of new 1,2,3-diazaborine derivatives and analogues.

These provide valuable opportunities for structure- or catalytic mechanism-based design of selective inhibitors as novel anti-TB drugs with improved properties. Global tuberculosis control – surveillance, planning, financing.

Tuberculosis, focus on tropical diseases. Chemotherapy of experimental tuberculosis – V. This paper highlights recent approaches regarding the design of new anti-TB agents, particularly, the enoyl-ACP reductase inhibitors.

Microbial pathogenesis of Mycobacterium tuberculosis: Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents.