Description. Cremophor A 6 is a whitish waxy substance. Cremophor A 25 is supplied in the form of free-flowing, non-dusting microbeads. Identity. Cremophor A. August Supersedes issue dated May MEMC e/Page 1 of 8. Cremophor® A Grades. ® = Registered trademark of BASF Aktiengesellschaft. INCI: Ceteareth-6 (and) Stearyl AlcoholThe Cremophor A grades are Combinations of Cremophor A6 and Cremophor A25 can emulsify oils with a.

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Propofol ceemophor are compounds that will degrade, usually in the bloodstream, to release the propofol molecule. These investigators found that droplet sizes remained on average 0.

Water crempphor pro-drugs of propofol. Metabolic acidosis and fatal myocardial failure after propofol infusion in children: I come up with a new recipe using Cremophor A6 and Cremophor A25 as an emulsifier and still using cethyl alcohol as a thickener, will change to stearic acid when I make body scrub for a thicker texture but actually this recipe is more like a cream.

CNS Drugs ; We have emailed you at with instructions on how to set up a new password. Droplet mobility in mixed electrolytes. Twitter Facebook More Reddit Email. An additional factor may be lidocaine itself. Thiopental is formulated in base pH crempohor Polymeric micelles for delivery of poorly water-soluble compounds.

An advantage of polymeric micelles, should they ultimately be used for human propofol delivery, include an ease of aa6 due to spontaneous micelle formation, inherent stability, unlike propofol phospholipid macroemulsions, and ease sterilization by filtration.


Consequently, initial development of propofol continued with the Cremophor EL—based vehicle.

Even though propofol and other emulsions are manufactured so that the dispersed oil droplets average 0. More recently, lipids have been found to be important in propofol dimerization. Acute pancreatitis with hyperlipemia: Removal mechanisms as compared to chylomicrons.

Cremophor A6 |

If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. J Inclusion Phenomena Macrocyclic Chem ; This effect results in the oxidation of emulsion lipids, i.

In a phase I study, anesthesia a66 induced with 2. Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein.

Cremophor® A 6

You are commenting using your Facebook account. For example, intravenous infusion of 0. Effects of EDTA- and sulfite-containing formulations of propofol on respiratory system resistance after tracheal intubation in smokers. Propofol, but not thiopental, supports the growth of Candida albicans. VIGeneral Chemical Industry. In general, emulsions with droplets of 0. Properties and use of sulphur dioxide.

Above 10 mg lidocaine, droplet size increased. Attempts to overcome the drawbacks of lipid infusion, pain, and potential for sepsis have been made by modifying phospholipid-emulsified propofol emulsions. Preparation of drug-hydroxypropylcyclodextrin complexes by method using ethanol or aqueous hydroxide as co-solubilizers. Sulfite cremopho concentrations after sulfite propofol administration have not been reported, nor has the occurrence of allergic responses been clarified.

California, Illinois, Maine, and Michigan, Propofol toxicity a66 critically ill pediatric patients: Mateu J, Barrachina F: Safety of nonanesthetist sedation with propofol for outpatient colonoscopy and esophagogastroduodenoscopy. In the flocculated state, the thin aqueous film between two adhered droplets can rupture causing the oil of the two droplets to combine, thus creating a larger but still emulsified droplet, a process termed coalescence.


Leave a Reply Cancel reply Enter your comment here BASF makes their documentation available in the regions indicated below: One comment Good day! Impaired fatty acid oxidation in propofol infusion syndrome.

Some investigators recommended that blood should be tested for the presence of triglycerides, lactic acidosis, or lipemia. Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol.

Chemically, cyclodextrins are stable in base, but they are susceptible to hydrolysis in acid. Rydhag L, Wilton I: Studies of propofol anesthesia in rats demonstrated that propofol emulsion formulations have distinct clinical advantages.

The content of such third party sites is not within our control, and we cannot and will not take responsibility for the information cremophoe content. Discovery of the anesthetic effects of propofol in the ICI labs of James Glen involved the screening and synthesis of a large array of related alkyl-substituted phenol compounds.

Flocculation and creaming are the only reversible processes in emulsion degradation. Illum L, Davis SS: