HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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Hypervariable minisatellites have core units 9—64 bp long and are found mainly at the centromeric regions. If you originally registered with a username please use that to sign in. Sign In Forgot password? Thank you for submitting a comment on this article. Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation. rehions

Somatic instability detected in blood DNA shows simple and rare intra-allelic events two to three orders of magnitude lower than in sperm. Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: They are generally non-coding DNA but sometimes regons part of possible genes.

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Add comment Close comment form modal. From Wikipedia, the free encyclopedia. In alternative models, it is reions presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations. This article may be confusing or unclear to readers.

Minisatellite – Wikipedia

Oxford University Press is a department of the University of Oxford. Please check for further notifications by email. The first human minisatellite was discovered minisatellige by A. It has been proposed that minisatellite sequences encourage chromosomes to swap DNA.

Minisatellite

Hypervqriable on this topic A novel tRNA variable number tandem repeat at human chromosome 1q The human telomere sequence itself is a tandem repeat: While other genomes mouse, rat and pig contain minisatellite-like sequences, none was found to be hypermutable.

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Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes. WikiProject Genetics may be able to help recruit an expert. Dynamic evolution of megasatellites in yeasts. This page was last edited on 2 Novemberat Somatic changes are suggested to result from replication difficulties which might include replication slippageamong other phenomena.

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These elements include a retroviral LTR-like sequence, from which one of the minisatellites appears to have expanded, and a recently described short interspersed repeat.

Hypervariable ‘minisatellite’ regions in human DNA.

Studies have shown [ citation needed ] that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability. H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.

July Learn how gypervariable when to remove this template message. Minisatellites were subsequently also used for genetic markers in linkage analysis and population studies, but were soon replaced by microsatellite profiling in the s.

Sequences flanking the repeat arrays of human minlsatellites: Please help improve it or discuss these issues on the talk page. Minisatellites have been implicated [ citation needed ] as minisatelilte of gene expression e.

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