PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.
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Brreast the power of linkage analysis in hereditary breast cancer. A new statistical test for linkage heterogeneity.
Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.
Strategies for multilocus linkage analysis in humans.
– Document – Linkage of early-onset familial breast cancer to chromosome 17q21
There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset. See Am J Hum Genet. However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested.
Genetic analysis of breast cancer in the cancer and steroid hormone study. Linkage of early-onset familial breast cancer to chromosome 17q Genetic epidemiology of breast cancer: This article has been cited by other articles in PMC. National Center for Biotechnology InformationU. Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.
Inheritance of human breast cancer: If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.
Closing in on a breast cancer gene on chromosome 17q. Segregation and linkage analysis of nine Utah breast cancer pedigrees.
Inheritance of proliferative breast disease in breast cancer kindreds. Associated Data Supplementary Materials.
Linkage of early-onset familial breast cancer to chromosome 17q21.
Am J Hum Genet. Open in a separate window. Support Center Support Center. This article has been corrected.
Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.
The detection and estimation of linkage between the genes for elliptocytosis and the Rh fzmilial type. Genetic epidemiology of breast cancer in Britain. Familial breast-ovarian cancer locus on chromosome 17qq